Eko Nurcahya Dewi1, Yuliani2, and Lukita Purnamayati1
1Department of Fish Product Technology, Faculty of Fisheries and Marine Sciences, Universitas Diponegoro, Jl. Prof. H. Soedarto, SH, Tembalang, Semarang 50275, Central Java, Indonesia
2Doctoral student of Departemen of Aquatic Resources, Faculty of Fisheries and Marine Sciences, Universitas Diponegoro, Jl. Prof. H. Soedarto, SH, Tembalang, Semarang 50275, Central Java, Indonesia
The aims of the research was to investigated the main bioactive component of Caulerpa racemosa microcapsules origin from North Sea Central Java Indonesia. The sample was subjected to high temperature (120 °C, 140 °C and 160 °C) for 5 hours through a bioinformatics approach. The present paper provides some useful bioinformatics database in silico approaches (Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiles. C. racemosa microcapsules were determined using Gas Chromatography-Mass Spectroscopy (GC-MS) as PASS database (Prediction of Activity Spectra for Substances) that it estimates of biological activity profiles for compounds. The results of GC-MS analysis indicated there was one volatile compounds that present on microcapsules were treatment to temperature 120 °C which is propane 2,2-diethoxy and there was three identified on compounds of microcapsules were treatment to temperature 140 °C which was furfural, 2-furancarboxaldehyde 5-methyl- and 3-fluoro-2,5-dimethyl-2,4-hexadien however no one appeared on160 °C. GC-MS analysis revealed microcapsule C. racemosa were treated to high temperature were detected compounds in the group alcohols, aldehydes, furans, and esters. The formation of most identified volatile compounds increased during heating, especially from 120 °C to 140 °C is compounds group of aldehydes and furans. PASS database revealed a potential C. racemosa microcapsules of the safety next-generation drugs that follow ADMET properties which is predicted to have anti-inflammatory properties